Can you take ibuprofen while drinking alcohol?

Avoid: Both alcohol and Ibuprofen can increase the risk of stomach ulcers and when used together, that chance is increased. Alcohol can lower your pain threshold while Ibuprofen generally increases it so these work at cross purposes. So the combination of the two is best avoid but you can have a light drink or two while on ibuprofen.

Avoid!: Ibuprofen, other non steroidal anti inflammatory medications, as well as aspirin, may lead to gastrointestinal bleed if taken with alcohol.

No: Both are irritating to the stomach, and the combination increases the risk of severe irritation (gastritis) or even bleeding. Alcohol should not be used for taking any medication and especially those that cause sedation or gastric irritation.