A member asked:

What is the difference between hemosiderosis and hemochromatosis?

13 doctors weighed in across 5 answers

Hemochrom is Genetic: Primary hemochromatosis is a genetic disorder that causes too much iron in tissues. It can be treated by removing a little blood every week or so. Hemosiderosis is not genetic. Can be caused by alcoholism or having many blood transfusions leading to excess iron in your cells.

Answered 6/19/2016

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Hemochromatosis: Hemochromatosis is an inherited disease in which too much iron builds up in your body. According to nih, it is one of the most common genetic diseases in the United States. Your body normally absorbs about 10 percent of the iron in the food you eat. If you have hemochromatosis, you absorb more iron than you need. This can cause damage to your organs.

Answered 6/19/2016

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Iron overload: Both are forms of iron overload disorders with different etiologies and pathophysiology. Hereditary hemochromatosis is caused by a gene mutation and involves deposition of hemosiderin (storage form of iron) in the organs of the body, such as the heart, liver, pancreas, and skin. The two types of hemosiderosis are idiopathic pulmonary and transfusion-related.

Answered 10/6/2016

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Finding vs illness: Hemosiderosis is extra iron in its storage form, from any cause. I may have this in a bruise that is resolving, or around the ankles if I have venous insufficiency. Hemochromatosis is a systemic illness (actually a group of genetic and acquired illnesses) in which there is too much iron in the body. It is always possible to demonstrate hemosiderosis in some tissue in hemochromatosis.

Answered 9/24/2016

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Acquired vs.: Genetic. Hemochromatosis is the result of a mutation in the iron metabolism gene and body absorbs more iron than needed and it gets deposited in tissues and causes disease. Hemosidrosis usually occurs in people who need repeated transfusions of red cells, e.g, sickle cell disease, or thalassemia, the excess iron in transfused red cells deposits in the tissues.

Answered 9/1/2018

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