Could you ever have an allergic reaction to ky jelly?

K-Y allergy: If you can be more specific of what your symptoms are, it would be easier to see if it is really an allergic reaction. In general, you can develop allergies or an allergic reaction to a variety of substances that are otherwise harmless. Most of the time, it is more likely that you get local irritations to k-y jell because of its various chemical components.