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A 37-year-old member asked:

How can i treat primary sclerosing cholangitis?

2 doctor answers8 doctors weighed in
Dr. Arthur Heller
Gastroenterology 44 years experience
Difficult problem: Psc: autoimmune swelling/scarring of bile ducts within and outside the liver; often associated with infl. Bowel (usually ulc colitis). Increased risk for biliary ca. Med rx for itch, biochem abnormalities, e.g. Urso (bear bile), antihistamines, antibiotics for infections, vitamin supllements for deficiencies. Ercp procedure may open some strictures (narrowing). Ultimately, may need liver transpla.
Dr. Shady Macaron
21 years experience
Ursodiol: Standard treatment includes ursodiol, a bile acid naturally produced by the liver, which has been shown to lower elevated liver enzyme numbers in people with psc, but has not improved liver- or overall survival. Invasive approaches include ERCP and stunting are needed to open major blockage. Liver transplant is the only proven long term treatment.

Similar questions

Alsip, IL
A 22-year-old female asked:

Is primary sclerosing cholangitis rare?

1 doctor answer10 doctors weighed in
Dr. Charles Cattano
Gastroenterology 40 years experience
Yes: The goal of managing acute attacks is antibiotics and IV fluids. In about 15%, emergency decompression or surgery is needed. Prevention of future attacks of cholangitis is based on removing biliary stones and debris, dilation or resection of strictures, and establishing optimal biliary drainage. Also important to rule out the clonorchis parasite. Your GI doctor can discuss newest treatments.
A 35-year-old member asked:

Primary sclerosing cholangitis - what is the inherited risk?

1 doctor answer1 doctor weighed in
Dr. Gerardo Garcia
General Surgery 34 years experience
Very low: PSC is most commonly seen in patients with ulcerative colitis. Patients with PSC have 60-72% association with ulcerative colitis; low genetic and immunologic factors are attributed to PSC.
A 34-year-old member asked:

Will primary sclerosing cholangitis kill me?

1 doctor answer2 doctors weighed in
Dr. Valentin Drezaliu
Obstetrics and Gynecology 21 years experience
Yes: It is a disease that slowly progresses and eventually without treatment leads to hepatic failure which has a very high mortality rate.
A 27-year-old member asked:

Do people with primary sclerosing cholangitis have a lot of pain?

2 doctor answers7 doctors weighed in
Dr. Jennifer Anyaegbunam
Dr. Jennifer Anyaegbunamanswered
General Practice 8 years experience
Depends: Primary sclerosing cholangitis ( psc) causes destruction of the bile ducts inside and outside of the liver. The first symptoms of the disease include fatigue, itching and jaundice, or yellowing of the skin and eyes. Psc however, is associated with a number of hepatobilliary disorders like pancreatitis, which may cause pain.
Dr. Quang Nguyen
Specializes in Endocrinology
Mar 14, 2012
Last updated Sep 9, 2018
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