A member asked:

Can diphenhyrdramine hcl 25 mg antihistamine cause a positive urine test?

A doctor has provided 1 answer
Dr. Michael Zacharisen answered

Specializes in Allergy and Immunology

For antihistamine: Diphenhydramine is commonly called Benadryl (diphenhydramine) and used as a sleep aid and for treatment of allergies. It should not lead to a positive illicit drug urine test. If urine is testing for antihistamines, it will be positive.

Answered 6/8/2021

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