Can ana fluctuate in the winter vs. summer? had rash in winter that was possible early connective tissue disease per biopsy. have more pain in winter.

Possibly: Advise you see your rheumatologist and have titers checked. Connective tissue diseases can fluctuate in severity with the seasons, and many factors play a role.

Perhaps, but sx more: There 100+ ct diseases (immunologic disorders (where one makes antibodies to own tissues); typical e.g. Are systemic lupus, scleroderma, rheumatoid arthritis, psoriasis; often can't categorize (mixed ct disease); rash or pain in winter may be cold air setting off small artery spasm (reynauds). ANA titer fluctuation not very important. Gloves, ear muffs, scarf, hand/feet warmers; rheumatologist.