A member asked:

What are side effect of intaking of melformine hydrochloride sustained release tablets and what is remedy to avoid side effect to some extent?

4 doctors weighed in across 3 answers

GI upset .Agree.: Metformin can cause GI upset in some people who take the medication. The extended release tablets tend to cause this side effect less often however it is still possible. Taking the medication with food can help. And the diarrhea and upset stomach can go away or lessen after someone has been on the medication for a while.

Answered 9/22/2019

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Dr. James Henning answered

Specializes in Anesthesiology

Consultation: With your md is strongly advised. But first, have a look at the link below for some basic info on side effects (G.I., etc.) and the need to involve your care team in the conversation. Your medical condition might require long-term adjustment of dosage, etc..Good luck! http://basicsideeffects.Com/metformin-glucophage-xr-side-effects-of-metformin/.

Answered 5/9/2013

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Dr. Victor Bonuel answered

Specializes in Internal Medicine

Metformin usually : Causes gastrointestinal side effects such as nausea, stomach upset/ cramping, diarrhea etc . Extended release tabs has lesser side effects/se than the regular tablets. Take the meds with food and lots of water to minimize these se. Take care!

Answered 10/13/2018

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