A member asked:

Hi doctor i'm a med. student and i've read in a lec. that sepsis can cause hypovolemic shock! can u explain the mechanism please regards?

A doctor has provided 1 answer

Yes it is true!: Sepsis when untreated, leads to septic shock and can cause multiorgan failure and death..The underlying cause is what is commonly called sirs(systemic inflammatory response syndrome) which is due to an overwheleming inflammation and immune activation, resulting in the release of cytokines like il-1, il-2, tnf and interferon-gamma which cause vasodilation and capillary leak resulting in hypovolemia.

Answered 5/2/2013

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