How long does depakote stay in your system?

Depends, see below: The half life of valproate is 16 hours. Depending on your drug levels at the time you stopped taking depakote, and assuming you did not start a new medication that interfered with the metabolism of depakote, in three to five days your levels were likely approaching zero.

It varies: Normally accepted half life is 4-16 hours but one recent study reported 40 hour. This means 1/2 of the total in your system should be gone in up to 40 hours.. Another 1/2 of whatever is left will take another 40 hours and so on. So there is no one clear simple answer. Best guess is that it will probably be gone by 10 days but could be sooner.