A member asked:

Which one is preferred paroxetine or vortioxetine for mdd and severe anxiety? can we combine both? which mood stabilizer considers the least side effects? thanks and please differentiate between paroxetine and vortioxetine?

A doctor has provided 1 answer
Dr. Samuel Galima answered

Specializes in Family Medicine

Paroxetine is an SSRI. Vortioxetine acts in a similar fashion. Paroxetine's side effects range from drowsiness, insomnia, weight gain, sexual dysfunction, and GI upset; however Vortioxetine only has the latter two. Paroxetine is used for many conditions including MDD and anxiety, but Vortioxetine is marketed only for MDD. There is a strong risk for Serotonin syndrome if taken together

Answered 9/10/2023

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