My grandma use 3 enama in a row and now i'm worry of the side effects?

It is unclear what you mean by “in a row”-do you mean 3 one after the other, 3 days in a row, etc? If she used 3 enemas all at once, the biggest concern is having loose stools and becoming dehydrated. She should be certain to increase her fluid intake to prevent dehydration. She should also see a doctor for constipation treatment-a GI doctor may be able to help treat her constipation. Good luck!