Does it hurt or burn a woman if they let a methamphetamine crystal dissolve inside their vagina?

Generally- it should not unless allergic to it

Most problems would be dose related. Absorbed that way you can't titrate the amount because of delay between absorption and effect. People overdose more frequently administering drugs this way. Once you realize you've taken too much your levels are still going up with nothing left to take back. If its cut with fentanyl you could die. Other contaminants or the meth itself can make you awful sick.