A member asked:

I itaking benedryl liquid at night to sleep is this safe for liver disease?

5 doctors weighed in across 3 answers

Research has shown that elderly people given diphenhydramine are more likely to show inattention , disorganized speech, and altered consciousness than those not taken this OTC medication. There is evidence that long term use can contribute to cognitive decline. Melatonin may be a safer and better OTC supplement to take than Benadryl. Only one case of liver disease has been reported from a big dose

Answered 2/24/2023

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Dr. Andrew Seibert answered

Specializes in Gastroenterology

Although it is generally safe with liver disease, it is probably not a good idea to use a sedative every night for sleep. If you are having difficulty sleeping, speak with your primary care doctor for a better solution. Good luck.

Answered 2/25/2023

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Several bad outcomes by taking Benadryl nightly: 1. Rapid onset of tolerance, where your sleep pattern deteriorates (learn a sleep hygiene program) 2. Benadryl has a significant anti-cholinergic effect, and your cognitive function will sharply worsen over time, especially at age 66. 3. Standard side effects include drowsiness, dizziness, confusion, and there is a falling risk.

Answered 2/25/2023

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