What could a high wbc with high neutrophils and low lymphocytes indicate?

Depends: The answer depends on the clinical situation, presenting symptoms, and medications. I see that you are on Prednisone which can elevate the neutrophils in the blood. It can also be seen in a number of other scenarios including infection.

Usu infection: This usually means a bacterial infection. But depending on how high each component is, it may be something else too.