Is it healthy to take an ssri antidepressant like cipralex for more than 3 years and to pause the treatment and take it for another 3 years or is it better to forget about cipralex after a treatment of 2-3 years? the depression almost disappeared?

When you feel better it's difficult to know if the condition improves spontaneously or because of medication's effect. However, with marked improvement, medication can be tapered then discontinued if there is no evidence of relapse. Once you are off the medication, it will only be restarted if symptoms recur. Drug holiday program is not used for antidepressants.