Soreness/achy to right calve. started randomly. sore to touch. should i be concerned?

Its most likely an over-exertion injury but we would need a lot more information. Particularly how long you've had this pain. If you smoke cigarettes and take birth control pills your risk of forming a blood clot is substantially increased. If this has been going on for a day or two and getting worse you should see a doctor or go to the emergency room