How is hyperthyroidism or a neuroendocrine tumor related to having bowel movements, at least twice in the middle of the night, every day, then 3 more times within an hour of waking up for the past 10 years even with a normal endoscopy and colonoscopy?

Those conditions can cause loose BM's. What does your gastroenterologist think your problem is? . It's unusual for simple IBS to awaken people.in the middle of the night with urgent loose BM's although it's possible. A fodmop diet can help IBS symptoms. Perhaps it's worthwhile to consult a gastroenterologist at a university hospital near you for a second opinion

They might. Endoscopy and colonoscopy cannot likely make a diagnosis of Neuroendo tumor or hyperthyroid as a cause Discuss with your team.