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A 26-year-old male asked:

What could cause elevated t4 total (11.5)? the ref range is 4.9-10.5. free t4 (3.6), tsh (1.15), t3 total (114), and t3 uptake (31) were all normal. symptoms of fatigue and gi (nausea, bad appetite and weight loss).is this overactive thyroid?

2 doctor answers2 doctors weighed in
Dr. Gurmukh Singh
Pathology 49 years experience
All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, your data is not diagnostic of hyperthyroidism. Unintended weight loss warrants evaluation by your doctor. Wish you good health!
Dr. John Berryman
Obstetrics and Gynecology 54 years experience
A condition called Plummer's disease can be caused by a hyperfunctioning thyroid nodule (thyroid adenoma) which does not follow normal hormonal mechanisms, and can suppress TSH disporportionally to the elevated T4 result. See a endocrinologist for a more detailed workup.

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Last updated Aug 4, 2021

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