Its cyclobenzaprine with seroquel is that safe?

Caution advised: cyclobenzaprine (generic) + Seroquel (quetiapine) caution advised: combination may increase risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

Not advisable: There are drug-drug interactional additive adverse effects, and not a wise choice. Would discuss this with your doctors, as would assume two different doctors were unaware of prescription of other. One of your meds should be held.