U.S. doctors online nowAsk doctors free
Hamilton, GA
A 49-year-old female asked:

Enbrel (etanercept) 50 mg sq x 3 months for ra + psoriasis. very little improvement. any downside to increasing to enbrel (etanercept) 50 mg sq twice weekly? mtx not tolerated.

2 doctor answers2 doctors weighed in
Dr. Thomas Namey
Rheumatology 49 years experience
Switch!: If not ccp antibody positive i would doubt ra. I would switch to Humira (adalimumab) 40 mg per week. Leflunomide would be an option!
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Robert Lowe
Pediatric Rheumatology 18 years experience
No real downside: Tnf inhibitors like Enbrel don't increase in toxicity like other meds do. Increasing the dose to 50mg twice weekly is a good idea.But, if you don't also take methotrexate, for any reason, you will be more likely to develop antibodies against the Enbrel and neutralize it--causing it to lose most or all effectiveness.If increasing Enbrel does not work, consider another med like Humira or remicade (infliximab).
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Jun 26, 2014

Disclaimer:

Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.