A member asked:

I started taking enbrel (etanercept) 5 weeks ago. major + response for 2 wks. now, irritation @ inject site +ra symptoms suddenly worse. is this typical? why?

6 doctors weighed in across 2 answers
Dr. Steven Sheskier answered

Specializes in Orthopedic Foot and Ankle Surgery

Irritation normal: Irritation at the injection site often occurs but if it occurs always and worsens with each injection you may be developing an allegryto the medication. If the happens or symptoms become worse se your prescribing/treating doctor, .

Answered 12/28/2014

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Takes more time: It will take Enbrel (etanercept) usually 3-4 months to reach its maximum effectiveness. Redness at the injection site is common and has no significance.

Answered 12/29/2022

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