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Lansing, MI
A 19-year-old female asked:

I took diphenhydramine hci 25 mg... antihistamine (benedryl) about 20 minutes before i had taken my 10mg lexapro and 1mg klonopin. i am currently experiencing drowsiness. is this unsafe? should i avoid taking benedryl with these other medications?

1 doctor answer1 doctor weighed in
Dr. Heidi Fowler
Psychiatry 27 years experience
Sedation: Drowsiness occurs in up to 50% of people taking Klonopin & in 1 to 10% of people taking benadryl. I certainly would not take benadryl and Klonopin together if you plan to operate a vehicle, work with dangerous machinery or if you need to remain wide awake.
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Last updated Apr 6, 2022


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