I have recently gotten off of the depo-provera shot. i have been off the shot for 5 months i have been having sever tenderness in my breasts why could this be?

Resuming cycles: It may be that the ovarian suppression from the depoprovera is now "wearing off" and they are now producing hormones (estrogen +/- progesterone) that are stimulating the breasts. While you were on depoprovera (which is injectable progesterone) you were not having as much ovarian production of estrogen. Vitamin e and reduction of caffeine helps breast pain. If no better, see your doctor.

Fibrocystic tissue: The most common reason for significant breast tenderness is fibrocystic breast disease. The Depo-Provera shot probably suppressed your ovaries which lowered your estrogen production. Stopping the Depo-Provera allows your ovaries to resume function, the increasing estrogen stimulates the mammary tissue causing increased pain. Mortrin and vitamin E would likely help the pain. If the pain persists, see your doctor.

Ovulation: The effects of the depoprovera have mostly worn off by now, so you may be ovulating now, which is a common cause of breast tenderness. It should go away when you get your period. Decrease caffeine, wear supportive bra, try evening primrose oil.