Does prozac and the eye drop timolo maleate interact with each other?

Yes. But...: Fluoxetine increases the level or effect of timolol (oral) by affecting an hepatic metabolism. It is recommended to avoid the interaction or use alternative treatments in those cases. However, in your case (eye drops) it is important to ask to your ophtalmologist about the possible drug interaction, which may be minimal since timolol drops acts directly in the eye.