Side effect hycamtin: Also known as topotecan. Yes severe diarrhea is a known side effect, as well as vomiting and nausea. There is medication to prevent or lessen these side effects. When nausea or diarrhea become severe it might lead to dehydration and more serious problems such as kidney failure. Stopping the drug to allow recovery and future dose reduction or discontinuing it altogether are options .
Answered 4/21/2018
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