A female asked:
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is it possible to become tolerant to bioidentical hormones (specifically estrogen) of any form (oral, transdermal, etc)?

1 doctor answer
Dr. Elizabeth Reynoso
17 years experience Obstetrics and Gynecology
No: No, you can not develop a tolerance to hormones. Hormone replacement therapy requires dose titration (move up and down the dose) in order to properly treat symptoms. Often drugs marketed as bioidentical have an inconsistent amount of hormone in them, especially some of the lotions and sprays available. If many doses aren't working, other, non hormonal, causes of symptoms should be ruled out
Answered on Feb 25, 2018

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