I wouldn't.: Tylenol with Codeine #4 (acetaminophen / codeine) plus Xanax (alprazolam) can cause CNS depression & lead to respiratory distress, coma,or death. Combining codeine & amitriptyline or mixing amitriptyline & Xanax can cause "dizziness, drowsiness, confusion, & difficulty concentrating" per DRUGS.COM.
Answered 11/14/2017
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