How far apart do you have to take oxycodome and lorazepam (ativan) to not overdose?

Major risk of combo: Using narcotic pain or cough medications together with other medications that also cause central nervous system depression can lead to serious side effects including respiratory distress, coma, and even death. Talk to your doctor about alternatives to avoid a major drug interaction here. Ref: https://www.drugs.com/interactions-check.php?drug_list=1488-0,1770-0

6 hrs: Plain codeine can be taken every 6 hrs and a benzodiazepine combination should be carefull as it may augment the side efffectd