Can i use fluticasone propionate nasal spray, fexofenadine hydrochloride & diphenhydramine hydrochloride at the same time?

Yes, but: The combination treatment of a topical nasal steroid spray such as fluticasone and a new generation antihistamine such as fexofenadine is a great combination. The use of old antihistamines such as Diphenhydramine (benadryl) is usually not necessary and carries more side effects. If symptoms are not controlled on this regimen seek advice from an allergist for a better plan.