A member asked:

Went to dr for clumsiness i had hyperreflexia legs/arms +jaw jerk +hoffman's sign +babinski & clonus. neuro ordered mri of brain what is she looking 4?

A doctor has provided 1 answer
Dr. Galina Nikolskaya answered

Specializes in Neurology

Broad ddx: There may be a bilateral cortical/subcortical brain disruption and MRI could help identify a potential cause based on the pattern of abnormalities. For ex: adult-onset leukodystrophy would show extensive demyelination of the white matter sparing the periventricular white matter vs MS vs Cerebral Autosomal-Dominant Arteriopathy, and work-up is different for each disease.

Answered 5/29/2018

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