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A member asked:
Is it possible that after a while a sickle cell patient body starts rejecting blood transfusions?
A doctor has provided 1 answer
Not really: There's no such thing as "rejecting" blood transfusion. Very rarely, someone can have a severe allergic reaction to transfused blood, with hemolysis (which as a sickle patient you may know a lot about). But this is exactly what blood typing is designed to prevent. If you think transfusions aren't boosting your hematocrit or hemoglobin as much as in the past, discuss it with your doctor.
Answered 4/9/2020
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