I have been on simvastatin for many years, started having leg pain, (worst in knee) x 12+ months. can statin cause/ worsen joint pain/ osteoarthritis?

Statin can but diagn: Statin can but it is usually muscle but we need a diagnosis of your leg pain. I assume you have been diagnosed as having osteoarthritis and if so statin would not in generla effect that but can cause leg tendon problems. You need to have a clear diagnosis to be certsin if the pain is osteoarthritis or something else.