Not allergy: Since opiates such as morphine directly releases histamine from the body cells, a good % of the people may end up with itching and even hives from it. But this is a chemical and not a truly allergic reaction and is usually dose-dependent. Opiates can cause sedation, stomach upset, and constipation but these are not from being allergic. Thus most if not all reactions are not allergic in nature.
Answered 11/5/2016
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