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A 40-year-old male asked:

How long after coming off aciphex (rabeprazole) until your system is normal. ?

3 doctor answers3 doctors weighed in
Dr. Julie Abbott
Preventive Medicine 46 years experience
A couple days: Aciphex/rabeprazole is a proton pump inhibitor: these drugs bind to an enzyme (proton pump) located on stomach parietal cells and block the production of hydrogen ions. So then the hydrogen ions can't combine with chloride ions to form gastric/stomach acid. This blockage/inhibition lasts about 48 hours after which new proton pumps are synthesized and resting proton pumps are reactivated. Stay well
Dr. Marissa Chesney
General Practice 13 years experience
24-48 hours: The medication has a half life of 1-2 hours, so it is no longer in your system somewhere between 3 and 12 hours after your last dose, depending on your individual metabolism of the medication.
Dr. Michael Safdi
Gastroenterology 47 years experience
Depends: What dose and how long did you take the Aciphex (rabeprazole)? Most people start making acid within 48 hrs. It may be slightly more than usual initially but should revert to normal within a week. Generally there are no other effects on your system.

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Last updated Sep 17, 2016
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