A member asked:

Are antidepressants potent antihistamines also?

3 doctors weighed in across 2 answers

Some are, yes.: Looking at receptor inhibition profiles (lab data) we can see that some do indeed block histamine receptors. Older ones in the tca class (elavil, anafranil, etc), trazodone and even a more modern one like Remeron (mirtazapine) do so which can lead to increased sleepiness and appetite. As far as potency, they're not as effective as sudafed in fighting a cold.

Answered 5/19/2016

5.2k views

Thank
Dr. Alan Ali answered

Specializes in Psychiatry

AD's: Some antidepressents have anticholinergic/antihistaminic effects.

Answered 5/26/2015

2.8k views

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