What is the cause of unilateral cleft lip, submucus palate, tongue tie and bifid uvula in a female baby with first degree relatives parents?

Genetics & developme: Due to a factor of genetic contributions many feel that a cleft lip and palate may be associated with persistently high riding tongue in the oral cavity as well as failure of mesodermal penetration.

Unknown: All 4 conditions can occur individually or in various combinations. Causes for congenital deformities (birth defects) can include environmental factors (maternal nutritional deficiencies), inherited factors as well as spontaneous mutations. Although incest is not common or considered advisable for humans, I am not aware of a specific correlation with orofacial deformities.

Many factors: Cleft lip and palate can occur in many syndromes as well as in patients with no other abnormalities. The origin of these abnormalities is multifactorial. Family history is a strong indicator for genetic causes. Strong evidence shows that environmental factors such as b vitamin deficiencies in the mother during pregnancy play a role. A consult can help to identify specific factors and risks.