Can i take nyquil if i'm on lisinopril 10mg and 100mg of topamax (topiramate)?

May be...: Since there is no drug which have been tested for their possible interactions with all others, it is hard to say yes or not. But based on the natures of these drugs, the odd for drug interaction should be low. So, you may use half recommended dose and see; if okay but not effective, take another half dose and see. Of course, asking your own doctor is best way to go since s/he knows more about you.