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A 21-year-old female asked:

Can i safely take phenergan (promethazine) several hours after drinking (like enough to get mildly drunk)? i know there is an alcohol interaction...

1 doctor answer1 doctor weighed in
Dr. Katherine Caldwell
Internal Medicine 18 years experience
Don't mix 2 sedative: The biggest side effect of phenergan (promethazine) is sedation (sleepiness), which will add to the effects of alcohol. I do NOT recommend taking phenergan (promethazine) until you are completely sober after drinking alcohol.
Last updated Mar 8, 2016


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