Can you get high on acetaminophen?

No: Do not take acetaminophen with alcohol. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, low fat milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex.

No: tylenol (acetaminophen) by itself should not have that effect. Tylenol (acetaminophen) can be harmful and even deadly if not taken appropriately though.