Can i take methylprednisolone 4mg and acetaminophen (tylenol) together? if so, should i limit the acetaminophen to a certain dosage?

No major interaction: acetaminophen/tylenol seems to have most of its action on the central nervous system, thus affecting the temperature setting brain, and the pain receiving brain. Methylprednisolone 4 mg is intended to over-ride your natural steroid production and decrease inflammation..it also affects virtually every cell. You can take together, and according to Rx.