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A 41-year-old male asked:

Can i take a sleep medicine with famotidine such as night time nyquil or tylenol (acetaminophen) pm?

1 doctor answer1 doctor weighed in
Dr. Efren Rael
Allergy and Immunology 19 years experience
Yes: Usually, there is no interaction with famotidine and nyquil or tylenol (acetaminophen) PM. Some recommend avoiding the combination with a different pain medication such as enteric-coated naproxen as the combination may result in premature dissolution of enteric coating, potentially increasing risk of stomach ulcers sometimes associated with naproxen.

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