Can allopurinol cause kidney failure?

Allopurinol: http://www.rxlist.com/zyloprim-drug/side-effects-interactions.htm Yes. especially if you have underlying renal disease. please discuss with your prescribing physician.

It's possible: It’s possible that allopurinol may contribute to kidney injury and failure, but what commonly happens when that’s the case is that it either combines with one or more drugs to harm the kidneys, or the kidneys are already not working well to begin with (the kidneys are responsible for getting rid of the drug from the body), and further harm occurs.