How long will take estradiol 2 mg work? i am having bad headache and hotflashes. just started pills today

10 to 14 days: It could take 10 to 14 days to notice an impact from the estrogen pill especially if your hormone levels wire abysmally low.

ERT: Within a couple days you should notice a difference and if not you may want to confirm you don't have thyroid issues as well. At 32 you may actually have better luck with a birth control pill with a moderate dose of estrogen and that uses norethindrone for the progesterone. Norethindrone also helps hot flashes.