Yes, it can: Sam-e is frequently combined with antidepressants. Unlike most medications, Sam-e should be taken on an empty stomach, otherwise it doesn't get absorbed. The starting dose is about 400 mg, but it can be increased to 1,200 mg and higher.
Answered 1/6/2018
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5 doctors weighed in across 2 answers
A doctor has provided 1 answer
A doctor has provided 1 answer
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