A member asked:

Can sam-e be taken with a antidepressant?

A doctor has provided 1 answer
Dr. Alexander Mauskop answered

Specializes in Neurology

Yes, it can: Sam-e is frequently combined with antidepressants. Unlike most medications, Sam-e should be taken on an empty stomach, otherwise it doesn't get absorbed. The starting dose is about 400 mg, but it can be increased to 1,200 mg and higher.

Answered 1/6/2018

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