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A member asked:
Started cymbalta (duloxetine) 60 mg one month ago. now experiencing hypersomnolence & ibs sx (constipation 1 day, diarrhea the next) . side effects?
2 doctors weighed in across 2 answers
Lower dose to 30: Yes,Cynbalta can cause somnolence because of its neurotransmitter norepinephrine, so should be taken at night to minimize such effect. Also has serotonine reuptake which can cause the diarrhea, although if you have IBS, it is difficult to know what is causing it. The diarrhea and the somnolence should inprouve with time, perhaps a more gentle titration should be considered(30Mg).
Answered 4/2/2015
3k views
Yes: Constipation is an unusual but difficult side-effect of Cymbalta (duloxetine). Most people feel stimulated with drugs like this but a small percentage will feel tired. You can try taking it in the evening and using some OTC for constipation (Metamucil will help both parts of IBS) but if theses things are severe this may not be the drug for you.
Answered 9/12/2020
3k views
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