If i took one 25mg benadryl (diphenhydramine) about 1-2 hours ago is it safe to take one more 25mg before bed?

Consider Options: Question is why are you requiring Benadryl (diphenhydramine) so often? If you have allergy symptoms that require antihistmines I would take non-sedating antihistamines during the daytime like Zyrtec, Allegra, or Claritin. They are longer acting and less sedating than Benadryl (diphenhydramine). Reserve Benadryl (diphenhydramine) for breakthrough symptoms and at night. That being said, if you have minimal sedation than another dose should be fine.

?DIAGNOSIS: Dosage of Benadryl (diphenhydramine) depends on body weight and diagnosis . Refer to the PDR. If your symptoms persist or worsen seek prompt evaluation

Yes it is safe: Yes 50 mgm of Benadryl(Diphenylhydramine) is a safe dose at bed time.Be careful as there may be some drowsiness during the day in some people But it is well tolerated without any ill effects in most of people