A member asked:

Does chantix release histamine?

3 doctors weighed in across 2 answers
Dr. Alan Wartenberg answered

Specializes in Addiction Medicine

Not that I know of: it acts on nicotine subreceptors (alpha2beta4 as I remember), and does not release histamine. I see you have a mast cell disorder, so you should be running this by the allerist/immunologist or rheumatologist you are seeing for that condition.

Answered 2/13/2015

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Dr. Paul Grin answered

Specializes in Pain Management

Definitely, no: Chantix is an alpha4beta2 nicotinic receptor partial agonist and also is an antagonist at histamine H1 receptors.

Answered 2/16/2015

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