Yes, usually: tapentadol is a strong opioid (narcotic) and a has a compound that reduces the breakdown of norepinephrine, Tapentadol only binds the mu opioid receptors Tramadol has less intense opioid action than tapentadol, but it binds a broader spectrum of opioid receptors. It inhibits breakdwon of serotonin. Tapentadol is 'stronger', for most people. Some people might not respond as well to it.
Answered 10/12/2020
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Yes: Nucynta is much stronger than tramadol
Answered 5/24/2017
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