A member asked:

Is tapentadol considered stronger than tramadol ?

3 doctors weighed in across 2 answers
Dr. Andrew Shiller answered

Specializes in Physical Medicine and Rehabilitation

Yes, usually: tapentadol is a strong opioid (narcotic) and a has a compound that reduces the breakdown of norepinephrine, Tapentadol only binds the mu opioid receptors Tramadol has less intense opioid action than tapentadol, but it binds a broader spectrum of opioid receptors. It inhibits breakdwon of serotonin. Tapentadol is 'stronger', for most people. Some people might not respond as well to it.

Answered 10/12/2020

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Yes: Nucynta is much stronger than tramadol

Answered 5/24/2017

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