My 33 y/o wife of 9 years has never had an orgasm from sex or toys/self.her obgyn says she is ok physically.psych says maybe anxiety - she has taken zoloft (sertraline) for this in the past. what can we do?

Sex therapist: Assuming that there are no detectable abnormalities physically or chemically, the best thing you could do is to see a sex therapist who is a certified clinical psychologist. Would assume this dates back to some childhood happenings and this can be brought out by a competent therapist. Remember that a high percentage of women have been molested or raped. Do not try to do this yourself. Get help.

Communicate: Ssri's like zoloft (sertraline) tend to lessen libido and so do bc pills decreasing likelihood. Orgasm most likely when most fertile. Genetic factors, stress, previous psychological trauma may play a role as well. Working patiently with a couple's therapist in a kind, supportive, environment using stories, humor, and imagination would be the best intervention.

Sexual fears: Many women have histories of rape or childhood abuse. I don't know whether this is the case with your wife, but if so, zoloft (sertraline) will not cure it. For some such women, sexual activity is so frightening that they can't explore/enjoy their own bodies' responses. If your wife regards your listed concerns as a problem, she could consult with a sensitive therapist. Healing will be a gradual process.