Can advair cause heart palpitations and arrhythmia's? is it normal? i'm on 250/50 for an asthma flare up.

Possible side effect: The salmeterol in the Advair can make your heart beat faster and feel like it's beating harder. It can less commonly cause irregular heart beats.

Yes, salmeterol is a: adrenaline [the primary neurotransmitter inducing both (a) lung smooth muscle (around all bronchioles) relaxation & (b) ↑ed heart rates (possibly arrhythmia) under brain control via direct nerve fibers to all these muscles 24/7] analogue, thus broad responses. Oral, SQ & IV meds cannot replicate this because go everywhere, thus side effects. Salmeterol attempts target only bronchial muscles.